Western Medicine Dexamethasone Tablets B.P. 0.5mg. (Palliative
treatment of rheumatoid arthritis)
Each uncoated tablet contains
Dexamethasone B.P. 0.5mg
To be used only by or on the prescription of a physician.
Dexamethasone is a well-tolerated antiinflammatory corticosteroid
which is approximately 25 times as potent as Hydrocortisone, and
6-10 times as potent as Prednisolone.
Dexamethsone has much less tendency to produce salt and water
retention,potassium depletion, edema, anorexia or psychic
Dexamethsone combines the anti-inflammatory and antiallergic effect
of Dexamethasone with the bacterial effect of Neomycin Sulphate and
should be preferred to the plain Dexamethasone for topical
treatment, whenever the presence of a local infection is suspected.
INDICATIONANS AND DOSAGE:
|Orally and intramuscularly:|
Palliative treatment of rheumatoid arthritis.
fever,addison's disease,still's disease.Waterhouse-liriderichen's
syndrome,allergies,serum sickness,drug sensitivity.
Depending on the severity of the disease and the susceptibility of
the patient, the initial dose usually is 3-4.5mg daily, and up to
6-9mg in severe asthma bronchiale, divided in 4 oral doses, or
given intramuscularly in one dose.
As soon as a good respond is noted the daily dosage is reduced
gradually by 0.5-1mg every two to three days, until the optimum
maintenance dosage is established (usual range between 1 and 4 mg
intramuscular injection is of value as a substitution for oral
therapy in seriouly ill or dahydrated patients or in patients
|Intraarticularly periarticularly intrabuisally or intrasynovially:|
to relieve inflammation and restore joint,function in rheumatoid
Average dosage for intraticuolar injection ranges from 1-2mg foe
smaller joints to 5mg for larger joints, in acute buraitis a daily
injection of 5mg for about 4 days is recommended.
Great technical care should be taken to ensure accurate injection
into joint cavitis,bureas or ganglia avoiding blood vessels and
other near-by tissues.
Although clinical investigations have shown that Dexamethasone
produces less undesirable effects than other corticosteroide. It
should be borne in mind that. Dexamethasone in an extremely potent
product and that therapeutic doses will, after asministration over
longer periods effect some depression on the function of the
adrenal cortex. The precautions for other corticosteroide should
therefore be followed, and it may be necessary to institute rest
periods and to stimulate adrenocortical function by use of ACTH.
If signs of injection are present, or if an infection is suspected,
Dexamethasone should be administered in conjunction with adequate
On occasion of therapy the drug should not be stopped abruptly, but
should be withdrawn gradually.
|Contra-indications:||Tuberculosis whether activem latent or arrested, other acute or
vhronic infections, diverticulitis, chickenpox, thrombophialebitis,
fresh intestinal anastomoses, peptic ulcer, psychotic tendences,
cushing's syndrome,vaccinia and varicella.|
Keep out of the reach of children.
Store in a cool dry place.
Protect from light.