Western Medicine PHENOXYMETHYLPENICILLIN TABLETS BP 400,000IU (an
antibiotic useful for the treatment of bacterial)
Each tablet contains:
Phenoxymethylpenicillin Potassium BP
Phenoxymethypenicillin BP 400,000IU
Phenoxymethylpenicillin, also known as penicillin V, is an
antibiotic useful for the treatment of a number of bacterial
infections. Specifically it is used for the treatment of strep
throat, otitis media, and cellulitis. It is also used to prevent
rheumatic fever and to prevent infections follow removal of the
spleen. It is given by mouth.
Side effects include diarrhea, nausea, and allergic reactions
including anaphylaxis. It is not recommended in those with a
history of penicillin allergy. It is relatively safe for use during
pregnancy. It is in the penicillin and beta lactam family of
medications. It usually results inbacterial death.
Phenoxymethylpenicillin was first made in 1948. It is on the World
Health Organization's List of Essential Medicines, a list of the
most important medication needed in a basic health system. It is
available as a generic medication. The wholesale cost in the
developing world is about 0.05 to 0.96 USD per day. In the United
States a course of treatment costs less than 25 USD.
Mild and moderate infection of penicillin V potassium tablets for
penicillin sensitive strain induced, including Streptococcus caused
by tonsillitis, pharyngitis, scarlet fever, erysipelas;
pneumococcal pneumonia, caused by bronchitis, sinusitis and otitis
media, sensitive Staphylococcus aureus caused by skin and soft
tissue infection. Penicillin V potassium tablets may also be used
for the prevention of infection and the use of drugs for the
prevention of recurrent rheumatic fever and infectious
1 each patient before taking penicillin V potassium tablets,
penicillin skin test must be carried out.
2 of cephalosporin allergy and disease history of allergic asthma,
eczema, hayfever, urticaria and other caution.
3 penicillin V potassium tablets and other penicillin drugs have
cross allergic. If there is an allergic reaction, it should
immediately stop penicillin V potassium tablets, and take
4 patients with impaired renal function should adjust the dose or
dosing interval according to the plasma creatinine clearance rate.
5 treatment of streptococcal infection need to be treated for 10
days, after the end of treatment should be used for bacterial
culture, to determine whether the removal of streptococcus.
6 patients with suspected syphilis associated with syphilis should
be examined by a dark field before the use of penicillin V
potassium tablets and, at least within 4 months, a monthly serum
7 long term or large doses of penicillin V potassium tablets,
should regularly check the liver, kidney, hematopoietic system
function and detection of serum potassium or sodium.
8 The interference of the laboratory index:
(1) copper sulfate method of urine test may be a false positive,
but glucose test method is not affected;
(2) the serum alanine aminotransferase or aspartate
aminotransferase determination value increased.
[Usage and Dosage]
|adult||1-1 1/2 tablets every 6 hours|
|Children (above 1 year)||1/2 tablets every 6 hours or as directed by the Physician|
Adult streptococcal infection: a 125 ~ 250mg, every 6 ~ 8 hours 1
times, treatment for 10 days.
Pneumococcal infection: a 250 ~ 500mg, 1 times every 6 hours, at
least 2 days after the treatment to fever.
Staphylococcal infection, spirochete infection (Vincent's angina):
spirochete infection (Vincent's angina): a 250~500mg, every 6 ~ 8
Prevention of recurrence of rheumatic fever: a 250mg, 2 times a
Prevention of endocarditis: in the tooth extraction or upper
respiratory tract surgery 1 hours before taking penicillin V
potassium tablets 2G, after 6 hours and then take 1g (27kg below
the child dose halved).
Children according to weight, once 2.5~9.3mg/kg, every 4 hours 1
times; or a 3.75~14 mg/kg, every 6 hours 1 times; or a 5~18.7
mg/kg, every 8 hours.
Penicillin skin test positive reaction, penicillin V potassium
tablets and other penicillin allergy and infectious mononucleosis
[Pregnant Women and Lactating Women Medication Notes]
1 penicillin V potassium tablets can enter the fetus through the
placenta, so pregnant women with caution.
2 penicillin V potassium tablets can be secreted into the milk, the
baby may cause sensitization and cause
[Elderly Medication Note]
Elderly patients should be adjusted according to the renal function
of the drug dose or interval.
1 common nausea, vomiting, abdominal discomfort, diarrhea and other
gastrointestinal reaction and black tongue.
2 allergic reactions: skin rash (especially in patients with
infectious mononucleosis), urticaria and other serum sickness like
reactions, laryngeal edema, heat and other drugs, such as
3: double infection or a large number of long-term use of
penicillin V potassium tablets can cause penicillin resistant
Staphylococcus aureus, gram negative bacilli or Candida albicans
infection (brown or black fur).
4 rare hemolytic anemia, transient increase of serum
aminotransferase, white blood cells, thrombocytopenia,
neurotoxicity and nephrotoxicity.
Specific indications for phenoxymethylpenicillin include:
Infections caused by Streptococcus pyogenes
Anthrax (mild uncomplicated infections)
Lyme disease (early stage in pregnant women or young children)
Rheumatic fever (primary and secondary prophylaxis)
Streptococcal skin infections
Spleen disorders (pneumococcal infection prophylaxis)
Initial treatment for Dental Abscesses
Moderate-to-severe gingivitis (with metronidazole)
Avulsion injuries of teeth (as an alternative to tetracycline)
Blood infection prophylaxis in children with sickle cell disease.
Penicillin V is sometimes used in the treatment of odontogenic
It is less active than benzylpenicillin (penicillin G) against
Gram-negative bacteria.Phenoxymethylpenicillin has a range of
antimicrobial activity against Gram-positive bacteria that is
similar to that of benzylpenicillin and a similar mode of action,
but it is substantially less active than benzylpenicillin against
Phenoxymethylpenicillin is more acid-stable than benzylpenicillin,
which allows it to be given orally.
Phenoxymethylpenicillin is usually used only for the treatment of
mild to moderate infections, and not for severe or deep-seated
infections sinceabsorption can be unpredictable. Except for the
treatment or prevention of infection with Streptococcus pyogenes
(which is uniformly sensitive to penicillin), therapy should be
guided by bacteriological studies (including sensitivity tests) and
by clinical response.People treated initially withparenteral
benzylpenicillin may continue treatment with
phenoxymethylpenicillin by mouth once a satisfactory response has
It is not active against beta-lactamase-producing bacteria, which
include many strains of Staphylococci.
Further information: Penicillin drug reaction
Phenoxymethylpenicillin is usually well tolerated but may
occasionally cause transient nausea, vomiting, epigastric distress,
diarrhea, constipation, acidic smell to urine and black hairy
tongue. A previous hypersensitivity reaction to any penicillin is a
[Mechanism of action]
It exerts a bactericidal action against penicillin-sensitive
microorganisms during the stage of active multiplication. It acts
by inhibiting thebiosynthesis of cell-wall peptidoglycan.
Store in a cool & dry palce.
Keep out of the reach of children