Western Medicine ROVIRON (Vitamin A + E Tablets) 30,000 IU/70mg
Ech chewable tablet contains:
Vitamin A 30,000 IU
Vitamin E 70mg
Adequate overage of vitamins added to
compensate for loss on storage.
Vitamin A is essential for growth and bone development, vision,
reproduction and maintenance fo the integrity of mucosal and
epitheial surfaces. Vitamin A defiviencies may lead to
xerophthalmia, rpithelial metaplasia of mucous membrances,
decreased resistance to infection (characteristic change in
rpithrlium of eye), night blindness and hperkeratosis of the skin.
The primary role of Vitamin E, a fat soluble vitamin, is the
preparation of oxidation of polyunsaturated fatty acids. Vitamin E
reasts with free radicals, which are the caus eof oxidation damage
to the cell membrances, without the formation of other free
radicals in the process. Vitamin E deficiency develops when the
dietary intake is inadequate althougt defiviency is rare. In
children with congential disorders such as cystic fibrosis or
biliary atresia malabsorption of fat may lead to a Vitamin E
deficinecy; similarly a deciency may occur in children with
abnormalities of lipid transport such adi in abetalipoproteinaemia.
Low Vitamin E concentrations are also foun din premature, very low
birth weight infants. Vitamin E is considered an essential element
of human nutrition. Many of its actions are related to its
antioxidant properties. Vitamin E deficiency rarely causes clincial
symptoms in adults. In premature neonates, irritability, edema,
thrombosis and hemolytic anemia may be caused by Vitamin E
Prevention and treatment of Vitamin A & E decificency. Vitamin
A helps form and maintain healthy skin, teeth, skeletal and soft
tissue, mucus membrances and skin. Vitamin A promotes good vision,
especially in low light. It may also be needed for reproduction and
breast0feefing. Vitamin E has been used to treat skin conditions.
leg cramps, sexual dysfunction, heart disease, aging, PMS and to
increase athletic performance. It also used in fants to cunteract
toxic effects of oxygen therapy on lunge & retina and to
prevenl hemolytic anemia in infants.
Hypersensitivity A; hypersensitivity to Vitamin A or any component
of a Vitamin A containing pharmaceutocal preparation.
Vitamin E is contraindicated in individuals with known history of
sensitivity or allergic reactions to the product or any of its
Adverse effects od Vitamin A include increased intracranial
pressure , headache, irritability, drownsiness, dizziness,
lethargy, vomitting, diarrhea, bulging of fontanels in infants,
diplopia, papilledema. Large doses may cause diarrhea, adominal
pain and other gastrointestinal disturbances and have also been
reported to cause fatigue and weakness. Contact dermatitis has
occurred following topical application.
Large doses of Vitamin E have been reported to increase bleeding
tendency in Vitamin K deficient patients such as those taking oral
coagulants. However it has also been suggested that it may
increased the risk of thrombosis in some patients, such as those
taking oestrogens. The clinical significance of these effects is
not known. A higer incidence of necrotizing enterocolitis has been
noted in premature infants weighing less than 1.5kg treated with
Vitamin E may increase the hypoprothrombinemic response to oral
anticoagulants and can intensify an existing coagulation defect
produced by Vitamin K deficiency that is the result of either
malabsorption or antioxggulant therpy. Doses in excess of
recommended daily nutrient intakes should be avoided in patients on
oral anticoagulants. Vitamin K status should be monitored in cases
Excessive consumption if Vitamin A supplements of foods rich in
beta-carotine such as carrots may cause carotenemia and yellow
discoloration of the skin. The sam effect may result from defetive
utilisation of Vitamin A precursos in
Various drugs may interfere with the absorption of Vitamin E
including cholestyramine, colestipol and orlistat. High doses of
Vitamin E may increase the effects of oral anticoagulante.
Excessive use of mineral oil as a laxative may reduce the
utilization of the provitamin by carrying aeay large amounts in the
feces. Choelstyramine and neomycin may affect drug absorption.
Vitamin A should not be used concurrently with isotretinoin since
toxic effects may be additive. Women on oral contraceptives have
shown a significant increase in plasma Vitamin A concentrations.
Matters needing attention
|1||chronic renal failure with caution.|
|2||patients with iron deficiency anemia.|
|3||With Hypoprothrombinemia in due to lack of vitamin K caused.|
|4||for the diagnosis of interference: chronic poisoning, blood
glucose, blood urea nitrogen, serum calcium, blood cholesterol and
triglyceride concentration increased. Large doses of red blood
cells and white blood cell count decreased, ESR, prothrombin time.|
[Pregnant and lactating women]
1 pregnancy on the requirement of vitamin A increased slightly, but
the daily intake of pregnant women should not be more than 6000
units, a large number of vitamin A have been reported may cause
fetal malformations, such as urinary tract malformation, growth
retardation, early epiphyseal healing.
2 vitamin A from milk secretion, increase the intake of lactating
mothers, should pay attention to the baby since the amount of
vitamin A in breast milk intake.
3 pregnant women should not exceed 1 pills a day.
4 excessive intake of vitamin A, and may be combined with early
pregnancy, pregnancy test should be done, and blood vitamin A
5 vitamin A overdose should be contraception.
6 pregnant women, such as excessive intake of vitamin A poisoning,
should be carried out without fetal risk consulting.
7 normal dietary intake of pregnant women, have not yet found a
definite lack of vitamin E, vitamin E can only get through the
placenta, fetal blood concentration of the mother of 20% - 30%, the
low birth weight infants after birth, because the storage is less,
lack of vitamin
[Medication for children]
1 infants are more sensitive to large or excessive vitamin A,
should be used with caution.
2 children must be used under adult supervision.
3 please put the medicine in the place where children can't get it.
[Medication in the elderly]
The elderly take vitamin A for a long time, probably due to
retinoic aldehyde and delayed clearance of excessive vitamin A.
In the case of overdosage, emesis or lavage should be empolyed.
Other measures include symptomatic management.
Chew oen table three times a day after meals.
3 x 10 tablets per pack.
Store in a cool and dark plce.
Keep all medicine out of reach of children.