Western Medicine Acetylsalicylic Acid BP500mg (ASPIRIN
Aspirin, also known as acetylsalicylic acid (ASA), is a medication
used to treat pain, fever, and inflammation. Specific
inflammatory conditions in which it is used include Kawasaki
disease, pericarditis, and rheumatic fever. Aspirin given shortly
after a heart attack decreases the risk of death. Aspirin is also
used long-term to help prevent heart attacks, strokes, and blood
clots in people at high risk. Aspirin may also decrease the risk
of certain types of cancer, particularly colorectal cancer. For
pain or fever, effects typically begin within 30 minutes.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and works
similar to other NSAIDs but also suppresses the normal functioning
Common side effects include an upset stomach. More significant side
effects include stomach ulcers, stomach bleeding, and worsening
asthma. Bleeding risk is greater among those who are older, drink
alcohol, take other nonsteroidal anti-inflammatory drugs (NSAIDs),
or are on blood thinners. Aspirin is not recommended in the last
part of pregnancy. It is not generally recommended in children with
infections because of the risk of Reye's syndrome. High doses may
result in ringing in the ears.
Each tablet contains Acetylsalicylic Acid (aspirin) BP 500mg.
Analgesic,antipyretic and niti-inflammatory.
Aspirin is used in the treatment of a number of conditions,
including fever, pain, rheumatic fever, and inflammatory diseases,
such as rheumatoid arthritis, pericarditis, and Kawasaki
disease. Lower doses of aspirin have also shown to reduce the
risk of death from a heart attack, or the risk ofstroke in some
circumstances. There is some evidence that aspirin is
effective at preventing colorectal cancer, though the mechanisms of
this effect are unclear. In the United States low dose aspirin
is deemed reasonable in those between 50 and 70 years old who have
a more than 10% risk of cardiovascular disease and are not at an
increased risk of bleeding who are otherwise healthy.
Dosage and Administration
Adults: 1 to 2 tablets, with halfat glass of water every 4 to 6
hours when necessary for not more than 10 days. Do not exceed 7
tablets in 24 hours inless directed by a physician.
Chlidren: Do not administer to children under 2 years of age unless
directed by the physician.
2 years:1/8 tablets. 3 to 5 years:1/4 tablets. 6 to 12 years:1/2
tablets. Over 12 years: 1 tables.
Active gastroduodenal ulcers, hypersensitivity to
salicylates,haemorrhagic disease,severe hepatic fonction
impairment,the last 3 months of pregnancy,concurrent use of
Precautions and Warnings
Use with caution in patients with chronic or recurrent stomach or
duodenal ulcers,gastric bleeding,severe renal disease,urticaria and
gout. Do not give to children under 2 years of age except on a
Asthmatics should consult their doctor before using preparations
containing aspirin. Because of the possible association between
Reye's syndrome and the ingestion of aspirin,care must be taken in
administering aspirin to children or teenagers with chicken
pox,influenza or fever.
Gastic irritation (mild gastic pain,heartburn) and increased
bleeding times have been reported.
Less common reactions include tinnitus,headache (the earlieat
symptoms of ovedosage) gastro intestinal ulceration and
Allergic and anaphylactic reactions include angioneurotic
oedema,urticaria,skin rashes and a severe ( and occasionallu fatal)
form of asthma have been reported.
Aspirin nhances the effect of:
Anticoagulants,coumarin,heparin,or thrombolytic agents.
Methotrexate salicylates may decrease renal clearance of
methotrexate leadina to toxic methotrexate plasma concerntrations,
if they are used concurrently,methotrexate dosage should be
Aspirin deereases the effects of:
(NSAID) non-streoidal anti-inflammatory drugs (decrease of
uricosuric agents. Aspirin increase the serum uric acid
concentration, diuretics (frusemide).
The effects of Aspirin may be decreased by concurrent use of
antacids. The alkalisation of the urine increase salicy late
excretion leading to decreased salicy late plasma concentration.
Mild overdose (salicylism):Continuous ringing or buzzing in earsmor
hearing loss and/or headache may be the earliest symptoms of
Severe overdose: Fever,excitement or
confusion,hyoerventilation,alternations in acid-base
balance:respiratory alkalosis and metabolic acidosis,hyper or
hypoglycaemia. Cardiovascular collapse and respiratory failure may
In young children the only sign of an overdose may be changes in
behaviour:severe drowsiness and tiredness and/or fhst or deep
T.e effects of overdosage in chlidren are dramatic and may be
Treatment: Transfer the patients to a specialised hospital setting.
Empty the stomach cia gastric lavage.
Monitor and support vital functions,correct fluid,electrolyte
Induce forced alkaline diuresis to increase salicylate excretion.
Exchange transfusion,haemodialysis,pertoneal dialysis could be
needed in severe overdosage.
Store below 30°C