Each ampoule contains500mg analgin
Analgin tablets are used for the treatment of pains of different
origin and variable intensity: toothache, headache, arthralgia,
neuralgia, myositis, mild to moderate visceral pain, high fever,
not responding to other drugs. Analgin injection is used in cases
of acute and severe pain after operations and traumas, pain
associated with neoplastic diseases, colicky pain etc.
4.Dosage and administration
Ampoules: The ampoules can be administered intramuscularly. The
single dose in all age groups is 8 to 16 mg/kg body weight. The
dose should be given according to the following scheme: 16 to 31 kg
body weight - 250 mg Analgin (1/2 ml); 32 to 46 kg body weight -
500 mg Analgin (1 ml); 47 - 62 kg body weight - 500 - 750 mg
Analgin (1 - 1.5 ml); and over 63 kg body weight - 750 - 1000 mg
Analgin (1.5 - 2 ml). In cases of persistent pain, the dose can be
repeated after 6 to 8 hours. Maximum daily dose - 4.0 g Analgin.
Analgin should not be used parenterally for a period longer than 3
days. Tablets: The dosage and duration of the treatment must be
determined according to the severity of the pain syndrome. The
common dose in the adults is 250 to 500 mg (1 to 2 tablets) 2 or 3
times daily. The maximum dose is 3 g/24h. In over 15 year-old
children the Analgin dose is 250 mg bid or tid.
Hypersensitivity to metamizole and other pyrazolone derivatives,
acute hepatic porphyria, inborn glucose-6-phosphate dehydrogenase
deficiency, severe renal or hepatic diseases, blood diseases (such
as aplastic anemia, leucopenia and agranulocytosis), pregnancy (the
first and the last trimester). Parenteral administration of Analgin
is contraindicated in under 1 year-old children.
6.Special warnings and precautions
Analgin is used with increased caution in patients with a history
for hypersensitivity to foods and drugs (particularly to analgesic
and nonsteroidal antiinflammatory agents) and also in patients
suffering from bronchial asthma, Quincke’s edema, chronic pulmonary
infections. In patients with hypotension and unstable blood
pressure, Analgin should not be used parentarally.
If Analgin application is quite necessary, the blood pressure and
the heart rate should be monitored. In cases of prolonged Analgin
treatment, regular blood count checks are necessary (differential
count of the white blood cells). The high Analgin doses can
influence unfavourably the active attention. Because of this in
these cases driving and working with machines are not advised.
Analgin potentiates the analgesic and antipyretic action of the
nonsteroidal antiinflammatory drugs. The Analgin effects are
potentiated by the tricyclic antidepressants, oral contraceptive
agents, allopurinol, alcohol. Analgin decreases the activity of the
coumarin anticoagulants and plasma levels of cyclosporin. The
enzyme inductors (barbiturates, glutethimide, phenylbutazone)
attenuate the Analgin effects. Analgin potentiates the effects of
the drugs possessing CNS depressant activity. Concurrent
administration with chlorpromazine is related with a risk of severe
hypothermia. Analgin can be used in combination with buscolysin,
After prolonged administration very rarely can be observed
agranulocytosis, leucopenia and thrombocytopenia, proteinuria,
interstitial nephritis. In sensitive patients rashes, urticaria,
Quincke’s edema, asthmatic attacks, and very rarely anaphylactic
shock are possible.
Analgin is a medicine of the pyrazolone group, possessing hard
analgesic and antipyretic effects and moderate antiinflammatory
activity. Blocking of the synthesis of endogenous pyrogens -
prostaglandins D and E - is the cause for the antipyretic activity
and also for the analgesic action of this drug. The decrease of the
prostaglandis production in the periphery (and respective decrease
of nerve endings sensitivity) plays a relatively smaller role. In
contrast to the other nonnarcotic analgesic drugs, Analgin
stimulates the release of β-endorphins, explaining its activity in
cases of visceral pain. Analgin has a slight spasmolytic activity
on the smooth muscle cells of the biliary and urinary tracts and
also on the muscle of the uterus.
500mg/5ml 0r 2.5g/5ml, ink printings or ceramic printings,
Store below 25°C (Air Conditioning). Protect from light.